Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer
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چکیده
منابع مشابه
Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer.
Over the past decade, numerous nonviral cationic vectors have been synthesized. They share a high density of positive charges and efficiency for gene transfer in vitro. However, their positively charged surface causes instability in body fluids and cytotoxicity, thereby limiting their efficacy in vivo. Therefore, there is a need for developing alternative molecular structures. We have examined ...
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15 صفحه اولVirus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer.
Gene therapy is based on the vectorization of genes to target cells and their subsequent expression. Cationic amphiphile-mediated delivery of plasmid DNA is the nonviral gene transfer method most often used. We examined the supramolecular structure of lipopolyamine/plasmid DNA complexes under various condensing conditions. Plasmid DNA complexation with lipopolyamine micelles whose mean diameter...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2004
ISSN: 1362-4962
DOI: 10.1093/nar/gnh153